Misun Hwang, MD

Misun Hwang, MD
Attending Radiologist
Assistant Professor of Radiology

Dr. Hwang is an Attending Radiologist within the Division of Body Imaging, Director of Neonatal Imaging, and an Assistant Professor of Radiology at the University of Pennsylvania. She received her Medical Degree from Vanderbilt School of Medicine and completed a Radiology residency at the University of Pittsburgh Medical Center and a Pediatric Radiology Fellowship at the Children’s Hospital of Philadelphia. She holds board certification in Diagnostic Radiology.

Dr. Hwang is a member of the Radiological Society of North America, American Institute of Ultrasound in Medicine, and Society of Pediatric Radiology. Dr. Hwang currently holds the NIH KL2 Career Development Award, the Investigator-Initiated Pilot Grant from Bracco, and the Foerderer Grant, Jaramillo Grant, and Junior Faculty Pilot Grant from CHOP.

Dr. Hwang’s passion for contrast-enhanced ultrasound research began during her medical studies while working with a mouse model of cancer to quantify tumor vascularity with intravascular microbubbles. After completing the Pediatric Radiology Fellowship at Children’s Hospital of Philadelphia, she joined Johns Hopkins Hospital as Assistant Professor of Pediatric Radiology and introduced the contrast-enhanced ultrasound technique. Her initial two years of faculty at Johns Hopkins Hospital were valuable as it was there that she began to explore the application of contrast-enhanced ultrasound for the characterization of brain injury in infants. Dr. Hwang went on to join Children’s Hospital of Philadelphia as the Director of Neonatal Imaging to oversee all aspects of conventional and advanced imaging studies performed in the neonatal division. She is currently the sponsor-investigator of the two Investigational New Drug (IND) studies approved by the Food and Drug Administration (FDA) on the application of contrast-enhanced ultrasound (CEUS) in neonatal hypoxic ischemic injury and necrotizing enterocolitis. She published the first clinical guidelines in the application of brain CEUS for evaluation of the brain in neonates and infants. Her second clinical research focus is to apply machine learning to integrate clinical and imaging parameters for improved diagnosis, therapeutic guidance, and prognostication. Dr. Hwang also performs preclinical research on development and validation of advanced ultrasound techniques. Her long-term goal is to provide pediatric patients with safe, highly sensitive, bedside advanced sonographic techniques as alternatives to transportation or radiation-requiring modalities during the critical period and find innovative approaches to combining diagnostics and therapy. Her significant achievements include:

  • Roentgen Award (2010)
  • Radiology BriteStar Awardee (2017)
  • RSNA (Radiologic Society of North America) Research Scholar (2017)
  • First Place Winner, New Investigator Competition at American Institute of Ultrasound in Medicine (AIUM) (2019)

Dr. Hwang is the sponsor-investigator of the two Investigational New Drug (IND) studies approved by the Food and Drug Administration (FDA) on the application of contrast-enhanced ultrasound (CEUS) in neonatal hypoxic ischemic injury and necrotizing enterocolitis.

Publication Highlights

  1. Hwang, M., Sridharan, A., Darge, K., Riggs, B., Sehgal, C., Flibotte, J., Huisman, TAGM. (2018) Novel quantitative contrast-enhanced ultrasound detection of hypoxic ischemic injury in neonates and infants: pilot study I. J Ultrasound Med. [Epub ahead of print]
  2. Hwang, M., Piskunowicz, M., Darge, K. (2019). Advanced ultrasound techniques for pediatric imaging. Pediatrics, 143(3), pii: e20182609.
  3. Hwang M. (2019). Introduction to contrast-enhanced ultrasound of the brain in neonates and infants: current understanding and future potential. Pediatr Radiol, 49(2), 254-262.
  4. Hwang, M., Riggs, B., Katz, J., Seyfert, D., Northington, F., Shenandoah, R., Burd, I., McArthur, J., Darge, K., Thimm, M.A., Huisman T.A.G.M. (2018). Advanced pediatric neurosonography techniques: contrast-enhanced ultrasonography, elastography, and beyond. J Neuroimaging, 28(2), 150-157.
  5. Thimm M, Rhee D, Cuffari C, Gearhart J, Hwang M: Diagnosis of Congenital and Acquired Focal Lesions in the Neck, Abdomen, and Pelvis with Contrast-Enhanced Ultrasound: A Pictorial Essay. European Journal of Pediatrics 177(10): 1459-1470, 2018.

Research Focus: Neonatal Imaging, Translational Research

External Links

Research Focus: 
Neonatal Imaging, Fetal Imaging, Pulmonary Imaging