Lisa J. States, MD

Lisa J. States, MD
Attending Radiologist
Associate Professor of Radiology

Dr. Lisa States is an Attending Radiologist within the Divisions of Body Imaging and Nuclear Medicine, the Director of the Section of Oncologic Imaging, and a Professor of Clinical Radiology at the University of Pennsylvania. She received her Medical Degree from Cornell University Medical Center and completed a Radiology residency at the Albert Einstein College of Medicine and a Pediatric Radiology Fellowship at the Children’s Hospital of Philadelphia. She holds board certification in diagnostic radiology and pediatric radiology.

Dr. States is a member of both national and international societies, including the World Molecular Imaging Society, International Society for Magnetic Resonance Imaging in Medicine, American College of Radiology, Society for Nuclear Medicine and Molecular Imaging (SNMMI), Radiological Society of North America, Children's Oncology Group, and Society for Pediatric Radiology. She is currently the President of the Pediatric Imaging Council for the SNMMI. Dr. States serves as a reviewer for the journals of the Journal of Nuclear Medicine, Clinical Nuclear Medicine, American College of Radiology, Pediatric Radiology, Future Oncology, and more.

Dr. States has been invited to give over 60 lectures both nationally and internationally. She has published papers, reviews, and editorials in journals such as Pediatric Radiology, Journal of Pediatric Surgery, Journal of Nuclear Medicine, and Clinical Cancer Research. She is author of over 50 abstracts presented at conferences such as the Society for Pediatric Radiology, Radiological Society of North America, Journal of Pediatric Surgery, and European Society for Pediatric Radiology annual meetings. In 2018, Dr. States received the “Be My Sugar Award for Medical Excellence” from Congenital Hyperinsulinism International. She is currently Principal Investigator on a project funded by the Alex’s Lemonade Stand Foundation (ALSF) BioTherapeutics Impact Award as well as two additional grants funded by industrial partners. Current projects include the evaluation and development of new radiotracers and Federated learning.

Over the past 20 years, Dr. States has dedicated her academic career to the advancement of pediatric imaging with a focus on pediatric oncology, magnetic resonance imaging, and pediatric nuclear medicine. As Director of the Section of Oncologic Imaging at CHOP, her current clinical research focus includes improving reporting and communication of oncology reports. Current projects include radiogenomics and personalized therapy in NBL, 18F-DOPA PET scan imaging for diagnosis of neuroendocrine tumors and focal lesions of congenital hyperinsulinism, and optimization and incorporation of PET/MR imaging into routine clinical practice. She is currently serves as investigator of the NIH-funded project “PennPET Explorer Scanner with Scalable Axial Length for Total Body PET.”

Notable career achievements include:

  • Sponsor and signatory of IND for investigative radiotracer 18F-DOPA.
  • Director of Oncologic Imaging at CHOP
  • Creation of a successful pediatric PET/MR program at a free-standing children’s hospital

Dr. States’ primary research focus is the evaluation of the efficacy of 18F-L-Fluoro-DOPA (F-DOPA) PET/CT scan for localization of focal pancreatic lesions in children with hyperinsulinemic hypoglycemia. She is co-investigator for the Next Generation Personalized Neuroblastoma Therapy (NEPENTHE) trial, which uses imaging to detect and guide biopsy of tumors to provide samples for genetic sequencing to create personalized treatment.

Publication Highlights

  1. States LJ, Saade-Lemus S, De Leon DD. 18-F-L 3,4-Dihydroxyphenylalanine PET/Computed Tomography in the Management of Congenital Hyperinsulinism. PET Clin. 2020 Jul;15(3):349-359. doi: 10.1016/j.cpet.2020.03.004.PMID: 32498990
  2. Adzick NS, De Leon DD, States LJ, Lord K, Bhatti TR, Becker SA, Stanley CA. Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children. J Pediatr Surg. 2019 Jan;54(1):27-32. doi: 10.1016/j.jpedsurg.2018.10.030. Epub 2018 Oct 5.PMID: 30343978
  3. States LJ, Reid JR Whole-Body PET/MRI Applications in Pediatric Oncology. AJR Am J Roentgenol. 2020 Sep;215(3):713-725. doi: 10.2214/AJR.19.22677. Epub 2020 Jul 8.PMID: 32755171
  4. Schmall JP, Surti S, Otero HJ, Servaes S, Karp JS. States LJ. Investigating Low-Dose Image Quality in Whole-Body Pediatric 18F-FDG Scans Using Time-of-Flight PET/MRI. J Nucl Med. 2021 Jan;62(1):123-130. doi: 10.2967/jnumed.119.240127. Epub 2020 Jun 1.PMID: 32482791
  5. Saade-Lemus S, Nevo E, Soliman I, Otero HJ, Magee RW, Drum ET, States LJ. Clinical pediatric positron emission tomography/magnetic resonance program: a guide to successful implementation. Pediatr Radiol. 2020 May;50(5):607-617. doi: 10.1007/s00247-019-04578-z. Epub 2020 Feb 19.PMID: 32076750
  6. MacFarland SP, Mostoufi-Moab S, Zelley K, Mattei PA, States LJ, Bhatti TR, Duffy KA, Brodeur GM, Kalish JM. Management of adrenal masses in patients with Beckwith-Wiedemann syndrome. Pediatr Blood Cancer. 2017 Jan 9;PubMed PMID:28066990.
  7. Borst AJ, States LJ, Reilly AF, Rheingold SR. Determining response and recurrence in pediatric B-cell lymphomas of the bone. Pediatr Blood Cancer. 2013 Aug;60(8):1281-6. PubMed PMID:23519982.
  8. Laje P, States LJ, Zhuang H, Becker SA, Palladino AA, Stanley CA, Adzick NS. Accuracy of PET/CT Scan in the diagnosis of the focal form of congenital hyperinsulinism. J Pediatr Surg. 2013 Feb;48(2):388-93. PubMed PMID:23414871; PubMed Central PMCID:PMC3597386.
  9. Greer ML, Voss S, States LJ: Pediatric Cancer Predisposition Imaging: Focus on Whole Body MRI. CCR Pediatric Oncology SeriesClin Cancer Res. AACR, 23(11): e6-e13, May 2017 Notes: DOI:10.1158/1078-0432.CCR-17-051
  10. States LJ, Voss S: PET/CT in Pediatric Oncology. Imaging in Pediatric Oncology. Voss SD, McHugh K (eds.). Springer Nature Switzerland AG, Page: 29-61, Jan 2019 Notes: Book chapter. Scan in the diagnosis of the focal form of congenital hyperinsulinism. J Pediatr Surg. 2013 Feb;48(2):388-93. PubMed PMID: 23414871; PubMed Central PMCID: PMC3597386.

Research Focus: Oncologic Imaging, Hybrid Imaging

External Links

Affiliations

  • Congenital Hyperinsulinism Center
  • Beckwith-Wiedemann Syndrome Clinic
  • Hyperinsulinism Frontier Program
Research Focus: 
Oncologic Imaging, Fetal Imaging